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KMID : 1145120180160040523
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Asian Journal of Beauty and Cosmetology
2018 Volume.16 No. 4 p.523 ~ p.531
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Anti-inflammatory and Collagen Production Effect of Syringic Acid on Human Keratinocyte (HaCaT) Damaged by Ultraviolet B
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Na Eun-Ju
Yang Hyun-Ok
Choi Young-Eun
Han Hyo-Sun
Rhie Sung-Ja
Ryu Ji-Young
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Abstract
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Purpose: The objective of this study is to examine the applicability of syringic acid as a cosmeceutical ingredient by examining its effects of inflammation suppression and collagen production for HaCaT (Cultured Human Keratinocyte) damaged by ultraviolet B.
Method: The gene expressions of syringic acid related to inflammation suppression and collagen production were confirmed through the quantitative realtime polymerase chain reaction (qRT-PCR). Changes in type I procollagen production were confirmed through the ELISA analysis.
Results: Syringic acid reduced the expressions of the inflammation related genes-interleukin 6 (IL6) , interleukin 1 beta (IL1β ), cyclooxygenase 2 (COX2 ) and tumor necrosis factor alpha (TNFα )-in HaCaT damaged by ultraviolet B in a concentration dependent manner. It also increased the gene expression of the collagen precursor, procollagen type I, in the same manner, consequently increasing the production of procollagen type I in a concentration dependent manner.
Conclusion: This study demonstrated the applicability of syringic acid as a natural phytochemical cosmeceutical ingredient that can suppress inflammation and produce collagen for HaCaT damaged by ultraviolet B in a concentration dependent manner. However, further human tests will be required to apply it to human skin as an actual cosmeceutical ingredient.
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KEYWORD
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Syringic acid, Anti-inflammatory, Collagen, Human keratinocyte, Ultraviolet B
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